Molecular Architecture of Proteins and Enzymes

Molecular Architecture of Proteins and Enzymes contains the proceedings of the 1983 U.S.-China Conference on Proteins in Biology and Medicine, held in Oklahoma City, Oklahoma. The papers focus on the molecular structure and function of proteins and enzymes in biology and medicine and cover topics ranging from the use of nuclear magnetic resonance in investigating the protein structure to regulation of the biological process and the structure and function relationships of blood proteins. Organized into three sections encompassing 18 chapters, this compilation begins with an overview of three serum proteins: alpha-2 macroglobulin and complement components C3 and C4. It then discusses the irreversible modification of enzyme activity, three-dimensional structures of scorpion neurotoxins, crystallographic studies on insulin and its analogs, peptide-receptor interactions that regulate cell proliferation, and molecular structure of plasma protease inhibitor genes in humans. It also explains the polymorphism of some serum proteins in the Chinese population and a new thrombin-dependent anticoagulant pathway. The book concludes with a chapter on antithromboplastin from Agkistrodon halys (Pallas) venom and its effects on the blood coagulation system. This book is a valuable source of information for biochemists, microbiologists, molecular biologists, and biophysicists.

Table of Contents:
Contributors Preface Structure and Function Relationships of Proteins Synthetic Models of the Metastable Binding Sites of Alpha-2 Macroglobulin and Complement Components C3 and C4 Kinetics of Irreversible Modification of Enzyme Activity Structure and Mechanism of Dopamine ß-Hydroxylase Studies on Snake Muscle Fructose-1,6-Bisphosphatase Three-Dimensional Structures of Scorpion Neurotoxins The Rapid Inactivation and Slow Conformational Changes of Creatine Kinase during Guanidine and Urea Denaturation Nuclear Magnetic Resonance for the Study of Protein Structure Structural and Functional Properties of E. coli L-Asparaginase Regulation of Biological Process Crystallographic Studies on Isulin and Its Analogs Peptide-Receptor Interactions That Regulate Cell Proliferation: The Epidermal Growth Factor System Studies on Structure and Biological Activity of Insulin Cholesterol Interaction with and Influence on Function of the Nicotinic Acetylcholine Receptor T Cell Control of Immunoglobulin Synthesis The Dissociation and Reassembly of Viral Capside Structure and Function Relationships of Blood Proteins Molecular Structure of Plasma Protease Inhibitor Genes in Man The Polymorphism of Some Serum Proteins in the Chinese Population Studies on a New Thrombin Dependent Anticoagulant Pathway Action of Antithromboplastin from Agkistrodon halys (Pallas) Venom on Blood Coagulation System Index