Molecular Mechanisms of Immunological Self-recognition
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Molecular Mechanisms of Immunological Self-recognition

Molecular Mechanisms of Immunological Self-recognition

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About the Book

The contributions in this book cover B cell tolerance, lymphocyte signalling, T cell tolerance and autoimmunity. The text should be of interest to technologists, molecular and cell biologists, physiologists, geneticists and microbiologists.

Table of Contents:
Immunological tolerance revisted in the molecular era, G.J.V. Nossal. Part l B cell tolerance - mechanisms and meaning of B lymphocyte tolerance, D. Nemazee; tolerant autoreactive B lymphocytes in the follicular mantle zone compartment - substrates for receptor editing and reform, C.C. Goodnow, et al. Part 2 Lymphocyte signaling - T cell anergy, B. Beverly, et al; the T cell antigen receptor - biochemical aspects of signal transduction, L.E. Samelson; structure and signaling function of B cell antigen receptors of different classes, M. Reth. Part 3 T cell tolerance - self-nonself discrimination by T lymphocytes, H. von Boehmer and B. Rocha; transgenic mouse model of lymphocyte development, D.Y. Loh; recognition requirements for the positive selection of the T cell repertoire - a role of self-peptides and major histocompatibility complex pockets, J. Nikolic-Zugic and M.J. Bevan; mechanisms of peripheral tolerance, G.J. Hammerling, et al; an analysis of T cell receptor ligand interaction using a transgenic antigen model for T cell tolerance and T cell receptor mutagenesis, P.A. Patten, et al; T cell repertoire and tolerance, A.M. Pullen, et al; sequential occurrence of positive and negative selection during T lymphocyte maturation, C.J. Guidos and I.L. Weissman; tolerance induction in the peripheral immune system, M. Wise, et al. Part 4 Autoimmunity - activation-induced cell death of effector T cells - a third mechanism of immune tolerance, C.A. Janeway, Jr. and Y. Liu; cells involved in inductive events in the pathogenesis of autoimmune diabetes mellitus, C.G. Fathman, et al; genetic control of diabetes and insulitis in the nonobese diabetic mouse - analysis of the NOD.H-2b and B10.H-2nod strains, L.S. Wicker et al; islet tolerance in humans and transgenic mice, N. Sarvetnick; fluorescence-activated cell sorter analysis of peptide-major histocompatibility complex, A.A. Sinha, et al; tolerance to self - a delicate balancer, E. Heber-Katz; prevention, suppression and treatment of experimental autoimmune encepholomyelitis with a synthetic T cell receptor v region peptide, H. Offner, et al. Part 5 Perspectives - tolerance of self - present and future, N.A. Mitchison.


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Product Details
  • ISBN-13: 9780120537501
  • Publisher: Elsevier Science Publishing Co Inc
  • Publisher Imprint: Academic Press Inc
  • Height: 230 mm
  • Weight: 540 gr
  • ISBN-10: 0120537508
  • Publisher Date: 31 Dec 1993
  • Binding: Hardback
  • Language: English


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Molecular Mechanisms of Immunological Self-recognition
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