Comprehensive Biomaterials

Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric BiomaterialsVolume 2: Biologically Inspired and Biomolecular MaterialsVolume 3: Methods of AnalysisVolume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other MoleculesVolume 5: Tissue and Organ EngineeringVolume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors.

Table of Contents:
Applications and preclinical studies; Biocompatibility; Biological and Tissue Analyses; Biologically Inspired and Biomolecular Materials and Interfaces; Biosensors; Cardiology and Cardiovascular Surgery; Ceramics; Computational Analyses and Modeling; Dentistry, and Oral and Maxillofacial Surgery; In vivo and Ex Vivo Imaging; Inorganic and Hybrid Controlled Release Systems; Mechanical Analysis; Metals; Micro-Fluidics – MEMS; Nanomaterials; Neurology and Neurosurgery; Ophthalmology; Organ Engineering; Orthopaedic Surgery; Polymers; Surface Engineering; Surgery; Systems Biology; Tissue Engineering

About the Author :
Paul Ducheyne is Professor of Bioengineering at the University of Pennsylvania, Philadelphia, USA, and a member of the Institute for Medicine and Engineering (IME) and the Center for Engineering Cells and Regeneration (CECR). Paul's research is focused in the investigation of mechanistic effects of materials on cellular functions, specifically cell attachment, proliferation, differentiation and extracellular matrix formation, especially with respect to biomaterials and tissue engineering. His lab works extensively with the interface zone between materials and cells and tissues, using both materials science techniques as well as life science methods. In addition, studies focus on the combined effects of microgravity and substrate material on cellular functions and on material surface modification and controlled release of growth factors. Several tissue engineering applications are pursued with orthopedic and dental applications. Specifically, his laboratory studies whether bone defects can be repaired with full return of mechanical function by treating defects with in vitro synthesized bone tissue. Paul Ducheyne is Professor of Bioengineering and Professor of Orthopaedic Surgery Research at the University of Pennsylvania, Philadelphia, USA. He is the Director of its Center for Bioactive Materials and Tissue Engineering. He also is Special Guest Professor at the University of Leuven, Belgium. Paul Ducheyne has Materials Science and Engineering degrees from the K.U. Leuven. Belgium (M.Sc.: 1972; Ph.D.: 1976). With fellowships from the National Institutes of Health (International Postdoctoral Fellowship) and the Belgian American Educational Foundation (Honorary Fellowship), he performed postdoctoral research at the University of Florida. Paul Ducheyne has organized a number of symposia and meetings, such as the Fourth European Conference on Biomaterials (1983), the Engineering Foundation Conference on Bioceramics (1986) which led to the New York Academy of Sciences publication: "Bioceramics, material characteristics versus in vivo behavior", and the Sixth International Symposium on Ceramics in Medicine (1993). He has lectured around the world and serves or has served on the editorial board of more than ten scientific journals in the biomaterials, bioceramics, bioengineering, tissue engineering, orthopaedics and dental fields. He has been a member of the editorial board, and then an associate editor of Biomaterials, the leading biomaterials journal, since its inception in the late seventies. He has authored more than 300 papers and chapters in a variety of international journals and books, and he has edited 10 books. He has also been granted more than 40 US patents with international counterparts. His papers have been cited about 7000 times; his ten most visible papers have been cited more than 2000 times. Paul Ducheyne started his career in Europe. While at the K.U. Leuven, Belgium (1977 - 1983), he was one of the co-founders of the Post-Graduate Curriculum in Bioengineering. This program is now a full M.Sc. program in the School of Engineering and Applied Sciences. In those initial years, he was also chairman-founder of the chapter on Biomedical Engineering of the Belgian Engineering Society (Flemish section) and director of Meditek, the Flemish Government body created to promote Academia to Industry Technology Transfer in the area of Biomedical Engineering. Paul Ducheyne founded Gentis, Inc., which focuses on breakthrough concepts for spinal disorders. Previously, he founded Orthovita (NASDAQ: VITA) in 1992 and served as Chairman of its Board of Directors until 1999. Orthovita focuses on bioceramic implant materials for orthopaedics. Paul Ducheyne has been secretary of the European Society for Biomaterials, is Past President of the Society for Biomaterials (USA) and Past President of the International Society for Ceramics in Medicine. He has been recognized as a fellow of the American Association for the Advancement of Science (AAAS), fellow of the American Institute of Medical and Biological Engineering (AIMBE), and fellow of the International Association of Biomaterials Societies. He was the first Nanyang Visiting Professor at the Nanyang Institute of Technology, Singapore and he has received the C. William Hall Award from the Society for Biomaterials. Many of Paul Ducheyne's trainees have become leaders of the next generation. Among his trainees are professors at the University of California at Berkeley, the University of Michigan, Columbia University, Georgia Institute of Technology, the K.U. Leuven (Belgium), etc... Among the six U.S. Associate Editors of the Journal for Biomedical Materials Research (the Journal of the Society for Biomaterials), three were his PhD students. Kevin E. Healy, Ph.D. is the Jan Fandrianto Distinguished Professor in Engineering at the University of California at Berkeley in the Departments of Bioengineering and Materials Science and Engineering. He received a Bachelor of Science degree from the University of Rochester in Chemical Engineering in 1983. In 1985 he received a Masters of Science degree in Bioengineering from the University of Pennsylvania, and in 1990 he received a Ph.D. in Bioengineering also from the University of Pennsylvania. He was elected a Fellow of the American Institute of Medical and Biological Engineering in 2001. He has authored or co-authored more than 200 published articles, abstracts, or book chapters which emphasize the relationship between materials and the tissues they contact. His research interests include the design and synthesis of biomimetic materials that actively direct the fate of embryonic and adult stem cells, and facilitate regeneration of damaged tissues and organs. Major discoveries from his laboratory have centered on the control of cell fate and tissue formation in contract with materials that are tunable in both their biological content and mechanical properties. These materials find applications in medicine, dentistry, and biotechnology. He is currently an Associate Editor of the Journal of Biomedical Materials Research. He has served on numerous panels and grant review study sections for N.I.H. He has given more than 200 invited lectures in the fields of Biomedical Engineering and Biomaterials. He is a named inventor on numerous issued United States and international patents relating to biomaterials, and has founded several companies to develop materials for applications in biotechnology and regenerative medicine. Distinguished Professor Dietmar W. Hutmacher is the Director of the Centre of Regenerative Medicine and Director of the Australian Research Council Centre in Additive Biomanufacturing at the Queensland University of Technology (QUT). He holds a MBA from the Royal Henley Management College and a PhD from the National University of Singapore. His career so far has included extensive work in research and industry as well as in education and academia. Hutmacher has expertise in biomaterials, biomedical engineering, and tissue engineering & regenerative medicine (TE&RM), and is also among the pioneers in the field of 3D printing in Medicine. He has published more than 250 journal articles, 24 book chapters, and 10 edited books. In 2012 he was elected to join the highly esteemed International College of Fellows Biomaterials Science and Engineering, and to become one of the 23 founding members of the International Fellows of Tissue Engineering and Regenerative Medicine Society (TERMIS). In 2013, he received the highly prestigious Hans Fischer Senior Fellowship from the Technical University in Munich. He has been an Adjunct Professor at the Georgia Institute of Technology for over a decade. Serving on the editorial boards of leading journals in his fields, Hutmacher maintains strong relationships within the global biomaterials, TE&RM and cancer research community. Over the last 18 years, he has been invited to give more than 50 plenary and keynote lectures at national and international conferences, has served on 30 organising committees for international conferences, and chaired more than 80 sessions. A number of medical device and tissue engineering projects have been patented and commercialized under his mandate, and he is a founder of 5 spin off companies. David W. Grainger is the George S. and Dolores Dore´ Eccles Presidential Endowed Chair in Pharmaceutics and Pharmaceutical Chemistry, past Chair of the Department of Pharmaceutics and Pharmaceutical Chemistry, and Chair and Professor of Bioengineering at the University of Utah, USA. Grainger received his Ph.D. in Pharmaceutical Chemistry from the University of Utah in 1987. With an Alexander von Humboldt Fellowship, he undertook postdoctoral research in biomembrane mimicry and assembly under Prof. Helmut Ringsdorf, University of Mainz, Germany. Grainger’s research focuses on improving implanted medical device performance, drug delivery of new therapeutic proteins, nucleic acids and live vaccines, nanomaterials interactions with human tissues, low-infection biomaterials, and innovating diagnostic devices based on DNA and protein biomarker capture. He also has expertise in perfluorinated biomaterials and applications of surface analytical methods to biomedical interfaces, including surface contamination, micropatterns, and nanomaterials. Grainger has published over 190 research papers at the interface of materials innovation in medicine and biotechnology, and novel surface chemistry. He has organized many international scientific symposia and chaired the Gordon Research Conference in Biomaterials and Tissue Engineering. He frequently lectures worldwide, including delivering many named, keynote, and plenary presentations. Grainger serves on the editorial boards of four major journals in the biomedical materials field. He is currently a Council member at the National Institutes of Health, and has served on many national and international review panels, including the NIH’s Surgery and Bioengineering and Emerging Bioanalytical and Imaging Technologies Scientific Review Groups. He remains active on academic scientific advisory boards for diverse academic programs in the United States, Asia, and Europe, including major research centers at the Universities of Wisconsin-Madison and University of Washington, the AO Foundation and EMPA, Switzerland, the Charité, Germany, several other competence centers in Europe.. Grainger also sits on the scientific advisory boards for four biomedical companies and actively consults internationally with industries in applications of materials in biotechnologies and medicine. His scientific and technical accomplishments are widely recognized, both at his institution and worldwide. Among several citations, Grainger is fellow of the American Association for the Advancement of Science (AAAS), the American Institute of Medical and Biological Engineering (AIMBE), and the International Union of the Societies of Biomaterials Science and Engineering. He has also been honored with the 2007 Clemson Award for Basic Research, Society for Biomaterials, and the 2005 American Pharmaceutical Research and Manufacturer’s Associa- tion’s award for ‘Excellence in Pharmaceutics’. C. James Kirkpatrick is Emeritus Professor of Pathology at the Johannes Gutenberg University of Mainz, Germany, having directed the Institute of Pathology from 1993-2015. Currently he is Senior Professor in the Cranio-Maxillofacial Surgery Clinic at the Goethe University of Frankfurt & Visiting Professor of Biomaterials & Regenerative Medicine at the University of Gothenburg, Sweden. He is also Honorary Professor at the Peking Union Medical College, Beijing and the Sichuan University, Chengdu, China. Kirkpatrick is a graduate of the Queen’s University of Belfast and holds a triple doctorate in science and medicine (PhD: 1977; MD: 1982; DSc: 1992). Previous appointments were in pathology at the University of Ulm, where he did postdoctoral research in experimental pathology, Manchester University (Lecturer in Histopathology) and the RWTH Aachen (Professor of Pathology & Electron Microscopy). On moving to Aachen in 1987, he established a cell culture laboratory which began using modern methods of cell and molecular biology to study how human cells react to biomaterials. Since then, his principal research interests continue to be in the field of biomaterials in tissue engineering and regenerative medicine, with special focus on the development of human cell culture techniques, including novel 3D coculture methodology for biomaterials and the application of modern molecular pathology techniques to the study of biofunctionality of biomaterials, including nanomaterials. Kirkpatrick is author/coauthor of more than 500 publications in peer-reviewed journals and has given more than 500 invited presentations to scientific meetings worldwide. He has an H-index of 58 (Web of Science) and 68 (Google Scholar) and has been cited more than 17.000 times. He is a former president of both the German Society for Biomaterials (2001–2005) and the European Society for Biomaterials (2002–2007) and served on the ESB council from 1995-2013. He was also a member of the Council of the European Chapter of the Tissue Engineering & Regenerative Medicine International Society (TERMIS-EU; 2006-2008; 2010-2012). Kirkpatrick was a long-standing member of the editorial board of the premier journal Biomaterials (1996-2014) and also associate editor (2002-2014). He has also served as associate editor of the leading Journal of Pathology (2001–2006). In total, he serves or has served as an editorial board member of 18 international journals in pathology, biomaterials, and tissue engineering. Kirkpatrick was the Scientific Programme Committee Chair for the 8th World Biomaterials Congress in Amsterdam in 2008. Kirkpatrick is a member of the Scientific Advisory Board of a number of research institutes, centres of excellence and companies in biomaterials and regenerative medicine in Europe, as well as the Medical Technology Committee, Federal Ministry of Education & Research in Germany (BMBF) (2005-2008) and the German Federal Institute for Drugs & Medical Devices (BfArM)(since 2007). Kirkpatrick has been recognized for his contributions. He is a Fellow of the Royal College of Pathologists, London and a Fellow of Biomaterials Science & Engineering (FBSE) of the IUS-BSE (International Union of Societies for Biomaterials Science & Engineering). He received the Research Prize of the State of Rhineland-Palatinate for Research on Replacement and Alternative Methods for Animal Research. He was the recipient of the George Winter Award from the European Society for Biomaterials (2008), and in 2010, he received, as first medical graduate, the Chapman Medal from the Institute of Materials, Minerals & Mining in London for “distinguished research in the field of biomedical materials”. In 2014 Kirkpatrick received the TERMIS-EU Career Achievement Award.

Review :
"In a highly technical and vastly broad subject area, the key to managing (mastering) reputable information and facilitating new breakthroughs is through its preservation and organization by experts in the field. For students or researchers wanting a quick introduction or a working knowledge of an unfamiliar subfield of biomaterials, the assembled chapters will be much more valuable than the typical documents that rise to the top of keyword searches. The authors and editors should be commended for their efforts and congratulated on producing an impressive reference of lasting value. In this reviewer's opinion, it will be an essential reference for any library affiliated with graduate programs in the biomedical sciences. Summing Up: Highly recommended. Upper-division undergraduates and above." --Choice "This is a huge body of work and I would suspect the price would preclude individual researchers from acquiring the set; however, this is a must have for libraries as an up-to-date reference for the current state-of–the-art information in this field as well as a fundamental reference tome for researchers seeking an introduction to the field." --Journal of Biomaterials Applications, February 2012