Williams Hematology, Seventh Edition

A Doody's Core Title ESSENTIAL PURCHASE! After six editions, Williams Hematology remains the cornerstone text in the literature for hematology. It’s discrete cell-by-cell approach has always been perceived as the most readily accessible by novices and experts alike, and now it is more clinical than ever through the inclusion of new key points boxes and algorithms that outline discrete strategies for diagnosis and treatment. There are also new chapters on the use of venous access devices, pain management, therapeutic use of cytokines, and flow cytometry. The latest moelcular biology techniques and 300 color plates enhance your diagnostic skills.

Table of Contents:
Contributors Preface SI Unit Conversion Table Part I: Clinical Evaluation of the Patient 1. Initial Approach to the Patient: History and Physical Examination, Marshall A. Lichtman and Ernest Beutler 2. Examination of the Blood, Daniel C. Ryan 3. Examination of the Marrow, Daniel H. Ryan and Raymond E. Felgar Part II: General Hematology 4. Structure of the Marrow and the Hematopoietic Microenvironment, Camille N. Abboud and Marshall A. Lichtman 5. The Lymphoid Tissues, Thomas J. Kipps 6. Hematology of the Newborn, George B. Segel and James Palis 7. Hematology During Pregnancy, Martha P. Mims and Josef T. Prchal 8. Hematology in Older Persons, Michelle Shayne and Marshall A. Lichtman Part III: Molecular and Cellular Hematology 9. Genetic Principles and Molecular Biology, Ernest Beutler 10. Cytogenetics and Gene Rearrangement, Lucy A. Godley and Michelle M. Le Beau 11. Apoptosis, Roberta A. Gottlieb 12. Cell Cycle Regulation and Hematological Disorders, Mathias Schmid and Dennis A. Carson 13. Signal Transduction Pathways, Kenneth Kaushansky 14. The Cluster of Differentiation (CD) Antigens, Thomas J. Kipps 15. Hematopoietic Stem Cells, Progenitors, and Cytokines, Kenneth Kaushansky 16. The Inflammatory Response, Jeffrey S. Warren and Peter A. Ward 17. Innate Immunity, Bruce Beutler 18. Dendritic Cells and the Control of Innate and Adaptive Immunity, Madhav Dhodapkar and Ralph M. Steinman Part IV: Therapeutic Principles 19. Pharmacology and Toxicity of Antineoplastic Drugs, Bruce A. Chabner, Wyndham Wilson, and Jeffrey Supko 20. Treatment of Infections in the Immunocompromised Host, Steven Beutler 21. Principles of Antithrombotic Therapy, Charles W. Francis and Karen L. Kaplan 22. Principles of Hematopoietic Cell Transplantation, Robert S. Negrin and Karl G. Blume 23. Principles of Immune Cell Therapy, Carolina Berger and Stanley R. Riddell 24. Principles of Vaccine Therapy, Larry W. Kwak 25. Principles of Therapeutic Apheresis: Indications, Efficacy, Complications, Bruce C. McLeod 26. Principles of Gene Transfer for Therapy, Januario E. Castro and Thomas J. Kipps 27. Pain Management, Weonjeong Lim, KaMala S. Thomas, and Joel E. Dimsdale Part V: The Erythrocyte 28. Morphology of the Erythron, Brian S. Bull 29. Composition of the Erythrocyte, Ernest Beutler 30. Production of Erythrocytes, Josef T. Prchal COLOR PLATES I-XXV (BETWEEN PAGES 404 AND 405) 31. Destruction of Erythrocytes, Ernest Beutler 32. Clinical Manifestations and Classification of Erythrocyte Disorders, Josef T. Prchal 33. Aplastic Anemia, George B. Segel and Marshall A. Lichtman 34. Pure Red Cell Aplasia, Neal S. Young 35. Anemia of Chronic Renal Failure, Jaime Caro 36. Anemia of Endocrine Disorders, Xylina T. Gregg and Josef T. Prchal 37. The Congenital Dyserythropoietic Anemias, Ernest Beutler 38. Paroxysmal Nocturnal Hemoglobinuria, Ernest Beutler 39. Folate, Cobalamin, and Megaloblastic Anemias, Bernard M. Babior 40. Disorders of Iron Metabolism, Ernest Beutler 41. Anemia Resulting from Other Nutritional Dificiencies, Ernest Beutler 42. Anemia Associated with Marrow Infiltration, Josef T. Prchal 43. Anemia of Chronic Disease, Tomas Ganz 44. Disorders of the Red Blood Cell Membrane: Hereditary Spherocytosis, Elliptocytosis, and Related Disorders, Patrick G. Gallagher 45. Disorders of Red Cells Resulting from Enzyme Abnormalities, Ernest Beutler 46. Disorders of Globin Synthesis: The Thalassemias, David J. Weatherall 47. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities, Ernest Beutler 48. Methemoglobinemia and Other Causes of Cyanosis, Ernest Beutler 49. Hemolytic Anemia Resulting from Physical Injury to Red Cells, Kelty R. Baker and Joel Moake 50. Hemolytic Anemia Resulting from Chemical and Physical Agents, Ernest Beutler 51. Hemolytic Anemia Resulting from Infections with Microorganisms, Ernest Beutler 52. Hemolytic Anemia Resulting from Immune Injury, Charles H. Packman 53. Alloimmune Hemolytic Disease of the Newborn, Jayashree Ramasethu and Naomi L.C. Luban 54. Acute Blood Loss Anemia, Robert S. Hillman and Chaim Hershko 55. Hypersplenism and Hyposplenism, Jaime Caro 56. Primary and Secondary Polycythemias (Erythrocytotis), Josef T. Prchal and Ernest Beutler 57. The Hematologic Aspects of Porphyria, Shigeru Sassa 58. Hereditary and Acquired Sideroblastic Anemias, Ernest Beutler Part VI: Neutrophils, Eosinophils, Basophils, and Mast Cells 59. Morphology of Neutrophils, Eosinophils, and Basophils, Dorothy Ford Bainton 60. Composition of Neutrophils, C. Wayne Smith 61. Production, Distribution, adn Fate of Neutrophils, C. Wayne Smith 62. Eosinophils and Their Disorders, Andrew Wardlaw 63. Basophils and Mast Cells and Their Disorders, Stephen J. Galli, Dean D. Metcalfe, Daniel A. Arber, and Ann M. Dvorak 64. Classification and Clinical Manifestations of Neutrophil Disorders, Marshall A. Lichtman 65. Neutropenia and Neutrophilia, David C. Dale 66. Disorders of Neutrophil Function, Niels Borregaard and Laurence A. Boxer Part VII: Monocytes and Macrophages 67. Morphology of Monocytes and Macrophages, Steven D. Douglas and Wen-Zhe Ho 68. Biochemistry and Function of Monocytes and Macrophages, Robert I. Lehrer and Tomas Ganz 69. Production, Distribution, and Fate of Monocytes and Macrophages, Tomas Ganz and Robert I. Lehrer 70. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages, Marshall A. Lichtman 71. Monocytosis and Monocytopenia, Marshall A. Lichtman 72. Inflammatory and Malignant Histiocytosis, Marshall A. Lichtman 73. Lipid Storage Diseases, Ernest Beutler Part VIII: Lymphocytes and Plasma Cells 74. Morphology of Lymphocytes and Plasma Cells, Stephen M. Baird 75. Composition and Biochemistry of Lymphocytes and Plasma Cells, Thomas J. Kipps and Dennnis A. Carson 76. Lymphopoiesis, Tucker W. LeBien 77. Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production, Thomas J. Kipps 78. Functions of T Lymphocytes: T Cell Receptors for Antigen 79. Functions of Natural Killer Cells, Giorgio Trinchieri and Lewis L. Lanier 80. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders, Thomas J. Kipps 81. Lymphocytes and Lymphocytopenia, Thomas J. Kipps 82. Immunodeficiency Diseases, Harry W. Schroeder, Jr. and Max D. Cooper 83. Hematological Aspects of Human Immunodeficiency Syndrome, Soon Thye Lim and Alexandra M. Levine 84. Mononucleosis Syndromes, Robert F. Betts Part IX: Malignant Diseases 85. Classification and Clinical Manifestations of the Clonal Myeloid Disorders, Marshall A. Lichtman 86. Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Leukemia), Marshall A. Lichtman and Jane L. Liesveld 87. Acute Myelogenous Leukemia, Jane L. Liesveld and Marshall A. Lichtman 88. Chronic Myelogenous Leukemia and Related Disorders, Marshall A. Lichtman and Jane L. Liesveld 89. Idiopathic Myelofibrosis (Myelofibrosis with Myeloid Metaplasia), Marshall A. Lichtman 90. Classification of Malignant Lymphoid Disorders, Thomas J. Kipps 91. Acute Lymphoblastic Leukemia, Ching-Hon Pui 92. Chronic Lymphocytic Leukemia and Related Diseases, Thomas J. Kipps 93.Hairy Cell Leukemia, Alan Saven 94. Large Granular Lymphocytic Leukemia, Thomas P. Loughran and Marshall E. Kadin 95. Pathology of Lymphomas, Randy D. Gascoyne and Brian F. Skinnider 96. The Non-Hodgkin Lymphomas, Kenneth A. Foon, Irene Ghobrial, Larisa J. Geskin, and Samuel A. Jacobs 97. Hodgkin Lymphoma, Sandra J. Horning 98. Plasma Cell Neoplasms: General Considerations, Stephen M. Baird 99. Essential Monoclonal Gammopathies, Marshall A. Lichtman 100. Plasma Cell Myeloma, Bart Barlogie, John Shaughnessy, Joshua Epstein, Ralph Sanderson, Elias Anaissie, Ronald Walker, and Guido Tricot 101. The Amyloidoses, Daniel R. Jacobson, David C. Seldin, and Joel N. Buxbaum 102. Macroglobulinemia, Thomas J. Kipps 103. Heavy Chain Diseases, Joel N. Buxbaum and Alice Alexander Part X: Hemostasis and Thrombosis 104. Megakaryopoiesis and Thrombopoiesis, Kenneth Kaushansky 105. Platelet Morphology, Biochemistry, and Function, Leslie V. Parise, Susan S. Smyth, Arun S. Shet, and Barry S. Coller 106. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostatis, Harold R. Roberts, Dougald M. Monroe III, and Maureane Hoffman 107. Control of Coagulation Reactions, John H. Griffin 108. Vascular Function in Hemostatis, Katherine A. Hajjar, Naomi L. Esmon, Aaron J. Marcus, and William Muller 109. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostatis, Uri Seligsohn and Kenneth Kaushansky 110. Thrombocytopenia, Reyhan Diz-Kucukkaya, Francisca C. Gushiken, and Jose A. Lopez 111. Essential Thrombocythemia and Thrombocytosis, Andrew I. Schafer 112. Hereditary Qualitative Platelet Disor ders, Barry S. Coller, W. Beau Mitchell, and Deborah L. French 113. Acquired Qualitative Platelet Disorders, Charles S. Abrams, Sanford J. Shattil, and Joel S. Bennett 114. The Vascular Purpuras, Phillip H.A. Lee and Richard L. Gallo 115. Hemophilia A and Hemophilia B, Harold R. Roberts, Miguel Escobar, and Gilbert C. White II 116. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors, Uri Seligsohn, Ariella Zivelin, and Aida Inbal 117. Hereditary Fibrinogen Abnormalities, Michael W. Mosesson 118. Von Willebrand Disease, Jill Johnsen and David Ginsburg 119. Antibody-Mediated Coagulation Factor Deficiencies, Jozef Vermylen and Jef Arnout 120. Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation, Ton Lisman and Philip G. de Groot 121. Disseminated Intravascular Coagulation, Uri Seligsohn and W. Keith Hoots 122. Hereditary Thrombophilia, Uri Seligsohn and John H. Griffin 123. The Antiphospholipid Syndrome, Jacob H. Rand and Lisa Senzel 124. Antibody-Mediated Thrombotic Disorders: Idiopathic Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia, J. Evan Sadler and Mortimer Poncz 125. Venous Thrombosis, Gary E. Raskob, Russell D. Hull, and Graham F. Pineo 126. Atherothrombosis: Disease Initiation, Progression, and Treatment, Emile R. Mohler III and Andrew I. Schaafer 127. Fibrinolysis and Thrombolysis, Katherine A. Hajjar and Charles W. Francis Part XI: Transfusion Medicine 128. Erythrocyte Antigens and Antibodies, Marion E. Reid, Loni Calhoun, and Lawrence D. Petz 129. Human Leukocyte and Platelet Antigens, Karen A. Sullivan and Thomas J. Kipps 130. Blood Procurement and Screening, Jeffrey McCullough 131. Preservation and Clinical Use of Erythrocytes and Whole Blood, Ernest Beutler 132. Preservation and Clinical Use of Platelets, Ralph Vassallo and Scott Murphy Index

About the Author :
Marshall Lichtman, M.D.Professor of MedicineUniversity of Rochester School of MedicineRochester, NY Ernest Beutler, M.D. Professor and Chairman Dept. of Molecular Medicine and Experimental Biology The Scripps Research Institute La Jolla, CA Senior Vice President, Health Sciences Dean, School of Medicine Stony Brook University Stony Brook, NY Evelyn and Edwin Tasch Chair in Cancer Research Professor of Medicine Division of Hematology/OncologyDeputy Director for Research Operations Moores UCSD Cancer Center University of California, San Diego La Jolla, California Professor of Medicine, Pathology, and Genetics Hematology Division University of Utah Salt Lake City, Utah Department of Pathophysiology First Faculty of Medicine Charles University in Prague Czech Republic