Advances in Enzyme Regulation

Volume 42 lives up to its goal of advancing a few steps ahead of the general front of mammalian enzymic and metabolic regulation studies. This volume contains papers of 25 outstanding scientists working at the cutting edge of metabolic regulation. Much of the volume focuses on novel aspects of signal transduction with an emphasis on nuclear expression. One of the highlights of this volume is the Special Symposium Lecture. This was given for 15 years by Sir Hans A. Krebs who passed away 20 years ago. It was now given by Professor Sir Hans L. Kornberg, University Professor at Boston University. These volumes continue to be a source of information and inspiration and a laboratory and advanced teaching companion. The immediate and long-range significance of these cutting-edge presentations of these novel topics should be immediately clear to the reader.

Table of Contents:
Foreword. List of Participants. Emery-dreifuss muscular dystrophy, nuclear cell signaling and chromatin remodeling (N.M. Maraldi, S. Squarzoni et al.). In situ detection of phospholipid and phosphoinositide metabolism (G.D. Prestwich, R. Chen et al.). Regulating the mammalian genome: the role of nuclear architecture (R. Berezney). Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase &ggr; in vitro (G.S. Kular, A. Chaudhary et al.). Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays (C. Sers, O.I. Tchernitsa et al.). Reciprocal regulation: recognition of pattern of gene expression in cancer cells (G. Weber). Detection of apoptosis in tumors using magnetic resonance imaging and spectroscopy (K.M. Brindle). Mitochondria and ceramide: intertwined roles in regulation of apoptosis (H. Birbes, S. El Bawab et al.). The importance of tumor metabolism in cancer prognosis and therapy; pre-clinical studies on rodent tumors with agents that improve tumor oxygenation (M. Stubbs, S.P. Robinson et al.). Overexpression of protein disulfide isomerase-like protein in a mouse leukemia L1210 cell line selected for resistance to 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone, a ribonucleotide reductase inhibitor (T.R. Crenshaw, J.G. Cory). Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis (N. Katunuma, H. Tsuge et al.). The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapies (J. Moscat, M.T. Diaz-Meco). Inositides in the nucleus: regulation of nuclear PI-PLC-&bgr;1 (L. Cocco, A.M. Martelli et al.). Regulation of phospholipase C-&ggr;1 by protein kinase A-dependent phosphorylation (Sun Sik Bae, Jang Hyun Choi et al.). DGK and nuclear signaling nuclear diacylglycerol kinases in IIC9 cells (L. Bregoli, B. Tu-Sekine et al.). The functional efficiency of lipogenic and cholesterogenic gene expression in normal mice and in mice lacking the peroxisomal proliferator-activated receptor-alpha (PPAR&agr;) (G.F. Gibbons, D. Patel et al.). Regulation of the activity of the pyruvate dehydrogenase complex (R.A. Harris, M.M. Bowker-Kinley et al.). Regulation of the intracellular localization of phosphoinositide-specific phospholipase c&dgr;1 (H. Yagisawa, M. Yamaga et al.). Lysosomal cathepsins: structure, role in antigen processing and presentation, and cancer (V. Turk, B. Turk et al.). Application of 15N to the study of hepatic nitrogen metabolism (J.T. Brosnan, M.E. Brosnan et al.). Regulation of glycolysis by Raf protein serine/threonine kinases (V. Le Mellay, R. Houben et al.). Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex (D.R. Mole, C.W. Pugh et al.). If at first you don't succeed...fructose utilization by Escherichia coli (H. Kornberg). Author Index. Subject Index.