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Strukturelle Untersuchungen zur anaplastischen Lymphomkinase

Strukturelle Untersuchungen zur anaplastischen Lymphomkinase


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About the Book

Die ALK-Tyrosinkinase wird als NMP/ALK-Fusionsprotein in etwa 60 % der Fälle von anaplastischem großzelligem Lymphom (ALCL) und in anderen Krebsarten wie nicht-kleinzelligem Lungenkrebs (NSCLC) und Neuroblastom exprimiert. Die konstitutive Aktivierung der ALK-Kinasedomäne ist für die maligne Transformation verantwortlich. Die strukturelle Charakterisierung der ALK-Kinasedomäne und Informationen über Wechselwirkungen zwischen Medikamenten und Proteinen könnten für die rationale Entwicklung neuer spezifischer Medikamente zur Behandlung von ALK+ ALCL und anderen ALK+ Tumoren sehr nützlich sein. Diese Arbeit konzentrierte sich auf die Herstellung und Reinigung verschiedener Formen der ALK-Kinasedomäne, um gute Kandidaten für ALK-Strukturuntersuchungen mittels Röntgenkristallographie und STD-NMR zu erhalten. Die beste rekombinante Proteinform wurde verwendet, um potenzielle ALK-Inhibitoren zu screenen und die Wechselwirkung zwischen der ALK-Kinasedomäne und einem neuen Kinase-Inhibitor nachzuweisen. Die Ergebnisse dieser Arbeit könnten den Weg für die Entwicklung neuer spezifischer Medikamente zur Behandlung von ALK+-Erkrankungen ebnen. Diese Arbeit könnte ein methodisches Modell für die Herstellung und Reinigung rekombinanter Proteine und für weitere Studien zur Wechselwirkung zwischen Medikamenten und Proteinen liefern.


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Product Details
  • ISBN-13: 9786200687029
  • Publisher: Verlag Unser Wissen
  • Publisher Imprint: Verlag Unser Wissen
  • Height: 229 mm
  • No of Pages: 196
  • Spine Width: 11 mm
  • Width: 152 mm
  • ISBN-10: 6200687021
  • Publisher Date: 16 Sep 2025
  • Binding: Paperback
  • Language: German
  • Returnable: N
  • Weight: 317 gr


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