Buy Conformation of Biological Molecules by Ramakrishna Hosur
close menu
Bookswagon
search
My Account
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Mathematics and Science books > Physics > Applied physics > Biophysics > Conformation of Biological Molecules: New Results from NMR(20 Wissenschaft und Kultur)
Conformation of Biological Molecules: New Results from NMR(20 Wissenschaft und Kultur)

Conformation of Biological Molecules: New Results from NMR(20 Wissenschaft und Kultur)


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

The determination of the three-dimensional structure of a biological molecule is the starting point in the understanding of molecular mechanisms involved in its complex biochemical reactions. The molecular architecture of multimolecular systems such as membranes and chromosomes provides the key to the fascinating field of molecular biology. Stereochemical details of biological macromolecules and their interactions with pharmacological agents form the basis for drug design. Naturally, the study of the structure and function of biological molecules has aroused tremendous interest and investigations in this area are being carried out in a large number of laboratories. The techniques used for this purpose include both experimental methods (X-ray and neutron diffraction measurements, study of NMR, ESR, vibrational and electronic spectra, ORD, CD and dipole moment measurements, biochemical modifications etc. ) and the- oretical methods (quantum mechanical and classical potential energy calculations, Monte- Carlo simulations and molecular graphics). F or several years now, X-ray diffraction [1] has served as our only source of infor- mation on the three-dimensional arrangements of atoms in biopolymers. Fiber-diffrac- tion of DNA led to the proposal of the DNA double helix. Fibers of long~hain polymers show ordering in the direction of the fibre-axis but not in the transverse plane. Accurate estimates of the dimensions of helical structures can be made using techniques on the basis of which models of biopolymers can be constructed.

Table of Contents:
1 General Theory.- 1.1 Introduction.- 1.2 What is Conformation?.- 1.3 Conformational Theory.- 1.4 Structure of Long-Chain Polymers.- 1.5 Problems in NMR Studies of Biological Molecules.- 1.5.1 1H-NMR.- 1.5.2 2H-NMR.- 1.5.3 13C-NMR.- 1.5.4 15N-NMR.- 1.5.5 31P-NMR.- 1.5.6 Other Nuclei.- 2 NMR Techniques in Conformational Studies.- 2.1 Coupling Constants.- 2.2 Chemical Shifts of Hydrogen-Bonded Protons.- 2.3 Magnetic Anisotropy of Chemical Bonds or Groups.- 2.4 13C Chemical Shifts.- 2.5 31P Chemical Shifts.- 2.6 Relaxation Times (T1 and T2).- 2.7 Nuclear Overhauser Effect.- 2.8 Paramagnetic Reagents.- 2.9 Use of Liquid Crystals as Solvents.- 2.10 Deuterium Quadrupole Coupling Constants.- 2.11 Solvent Accessibility.- 2.12 From NMR Parameters to Spatial Structures.- 3 Nucleosides, Nucleotides and Nucleic Acids.- 3.1 Description of Nucleotide Structures.- 3.2 Glycosidic Bond Rotations.- 3.3 Sugar Ring Conformation: Pseudorotation.- 3.4 Backbone Angles.- 3.4.1 Torsion Angles o ?.- 3.4.2 Angles o?.- 3.4.3 Angles ??.- 3.4.4 Torsion Angles ??, ?.- 3.5 NMR Studies on Nucleosides.- 3.6 Small Nucleotides.- 3.6.1 2?-, 3?- and 5?-Mononucleotides.- 3.6.2 Cyclic Nucleotides.- 3.6.3 Pyridine Nucleosides and Nucleotides.- 3.6.4 5?-Di- and Triphosphates.- 3.7 Dinucleoside Phosphates and Short Segments of Nucleic Acids.- 3.8 Random-Coil Polynucleotides.- 3.8.1 Oligo- and Polyribonucleotides.- 3.8.2 Deoxyribonucleotides.- 3.9 Helical Polynucleotides.- 3.10 t-RNA.- 3.11 Drug-Nucleic Acid Interactions.- 4 Amino Acids, Peptides and Proteins.- 4.1 Description of the Structure of Peptide Units.- 4.2 Theoretical Considerations. The o, ? Maps.- 4.3 NMR Techniques in the Study of Peptide Conformations.- 4.3.1 cis-trans Isomerization (Angle ?).- 4.3.2 o and ? Angles.- 4.3.3 Side-Chain Conformations.- 4.3.4 Detection of N-H...O=C Hydrogen Bonds.- 4.3.5 Molecular Symmetry.- 4.3.6 Conformational Mobility.- 4.3.7 1H and 13C Chemical Shifts.- 4.4 Conformations of Amino Acids.- 4.5 Linear Peptides.- 4.5.1 Dipeptides.- 4.5.2 Tripeptides.- 4.5.3 Tetrapeptides.- 4.5.4 Pentapeptides.- 4.5.5 Hexapeptides.- 4.5.6 Larger Peptides. Peptide Hormones.- 4.5.6.1 Angiotensin.- 4.5.6.2 Leuteinizing Hormone-Releasing Hormone (LRF).- 4.5.6.3 Peptides Containing a-Aminobutyric Acid (Aib).- 4.5.6.4 Human Parathyroid Hormone (PTH).- 4.5.6.5 Insulin.- 4.6 Cyclic Peptides.- 4.6.1 Dipeptides.- 4.6.2 Tripeptides.- 4.6.3 Tetrapeptides.- 4.6.4 Pentapeptides.- 4.6.5 Hexapeptides.- 4.6.6 Larger Cyclic Peptides, Peptide Hormones and Antibiotics.- 4.6.6.1 Oxytocin and Vasopressin.- 4.6.6.2 Gramicidin S.- 4.6.6.3 Valinomycin.- 4.7 Homopolymeric Peptides. Helix-Coil Transition.- 4.8 Characterization of Protein Structures by NMR.- 4.8.1 Spatial Arrangement of Atoms in the Molecules.- 4.8.2 Protein Mobility.- 4.8.3 Enzyme - Substrate Binding.- 4.8.4 Thermodynamic Parameters.- 4.8.5 Conformation of Specific Proteins.- 4.8.5.1 Lysozyme.- 4.8.5.2 Basic Pancreatic Trypsin Inhibitor (BPTI).- 4.8.5.3 Dihydrofolate Reductase.- 4.8.5.4 Antibody Combining Site.- 4.8.5.5 Myelin Basic Protein (MBP).- 4.8.5.6 Calcium-Binding Proteins.- 4.8.5.7 Elastin and Tropoelastin.- 4.8.5.8 Ribonuclease.- 4.8.5.9 Hemoproteins and Hemoenzymes.- 4.8.5.10 Collagen.- 4.8.5.11 ?-Chymotrypsin.- 4.9 Protein-Nucleic Acid Interaction.- 4.9.1 Specificity.- 4.9.2 Nature of Intermolecular Forces.- 4.9.3 Applications.- 5 Polysaccharides.- 5.1 Structures of Polysaccharides and Carbohydrates.- 5.2 Conformations of Monosaccharides.- 5.3 Conformations of Polysaccharides.- 5.4 Glycoproteins and Peptide-Carbohydrate Interactions.- 6 Lipids and Molecular Organization in Membranes.- 6.1 Biomembranes.- 6.2 General Properties of Phospholipids.- 6.3 Conformations of Phospholipids.- 6.3.1 Conformations of the Glycerol Moiety.- 6.3.2 Conformations in the ?-Chains.- 6.3.3 Conformations in the ? and ? Chains.- 6.4 Membrane Organization and Fluidity.- 6.4.1 Fluidity.- 6.4.1.1 Rotational Motions.- 6.4.1.2 Lateral Diffusion on the Surface of the Membrane.- 6.4.1.3 Flip-Flop Motions.- 6.4.2 Determination of Organization.- 6.4.2.1 31P-NMR.- 6.4.2.2 2H-NMR.- 6.4.2.3 Other Studies.- 6.5 Lipid-Protein and Lipid-Cholesterol Interactions.- 7 Acknowledgements.- 8 References.- 9 Appendix.- 10 Subject Index.


Best Sellers


Product Details
  • ISBN-13: 9783540107699
  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
  • Publisher Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Language: English
  • Series Title: 20 Wissenschaft und Kultur
  • Weight: 510 gr
  • ISBN-10: 354010769X
  • Publisher Date: 01 Nov 1981
  • Binding: Hardback
  • Returnable: N
  • Sub Title: New Results from NMR


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Conformation of Biological Molecules: New Results from NMR(20 Wissenschaft und Kultur)
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG -
Conformation of Biological Molecules: New Results from NMR(20 Wissenschaft und Kultur)
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Conformation of Biological Molecules: New Results from NMR(20 Wissenschaft und Kultur)

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!