Lyme Disease: An Evidence-based Approach

This new edition of Lyme Disease provides up-to-date evidence-based research and covers the significant advances in our understanding of the disorders referred to as Lyme disease or Lyme borreliosis. This book explores the causative organism, its requisite ecosystem, disease epidemiology, host-Borrelia interactions, diagnostic testing, clinical manifestations, therapeutic options, the role of host immunity on pathogenesis and long term prognosis. The authors provide balanced perspectives on all aspects of Lyme disease and explicitly review both the basic biology of the infection and practical clinical aspects. This new edition: Includes new borrelial pathogens that have been identified (B. miyamotoi, B. mayonii and B. bavariensis among others). Provides updated information on the molecular biology of the organism, neuroborreliosis, and the role of the C6 peptide in diagnosis. Discusses the controversies about 'chronic Lyme disease', post Lyme disease syndrome and other ongoing but non-specific symptoms that have been attributed to this infection. As the endemic footprint of Lyme disease continues to grow, this book provides a broad and detailed guide for clinicians and researchers involved with the diagnosis and treatment of the condition. Covering biology, epidemiology and therapeutics, it is also essential reading for students of global health and infectious disease.

Table of Contents:
PART I: BIOLOGICAL SUBSTRATE 1: Ticks: The Vectors of Lyme Disease 2: Biology of the Lyme Disease Agents: A Selective Survey of Clinical and Epidemiologic Relevance 3: Borreliella: Interactions with the Host Immune System 4: Diagnostic Testing for Lyme Disease 5: Global Epidemiology of Borreliella burgdorferi Infections PART II: CLINICAL ASPECTS 6: Antibiotic Therapy for Infection Caused by Borrelia burgdorferi Sensu Lato 7: Lyme Borreliosis: The European Perspective 8: Lyme Neuroborreliosis: A European Perspective 9: Medically Unexplained Symptoms and Lyme Neuroborreliosis – Not the Same: A Study in an Endemic Area of Norway 10: Erythema Migrans 11: Lyme Carditis 12: The Musculoskeletal Manifestations of Lyme Disease (Infection with Borrelia burgdorferi) 13: Nervous System Involvement 14: Lyme Disease in Children 15: The Psychology of ‘Post-Lyme Disease Syndrome’ and ‘Not Lyme’ 16: Chronic Lyme Disease 17: Lyme Disease: The Great Controversy

About the Author :
Educated at MIT and Harvard and received his clinical training at the University of Chicago and Massachusetts General Hospital. Currently Professor of Neurology and Medicine at New York's Mount Sinai School of Medicine, he began his career on the neurology faculty of SUNY Stony Brook, just as Lyme disease was being characterized. The multidisciplinary collaborative group there was able to substantially improve the knowledge base regarding this infection. An author or contributor to approximately 150 articles and chapters, Dr. Halperin lectures widely. He serves on the Guideline Development Subcommittee of the American Academy of Neurology, has been a long-standing examiner for the Neurology Board examination, and has been heavily involved in patient outcome improvement at Atlantic Health, the multihospital system in New Jersey where he now leads Neurosciences. Under his leadership, Overlook Hospital's Neuroscience program has rapidly become recognized as the state's best and busiest.