Handbook of Statistics in Clinical Oncology - Bookswagon UAE
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Handbook of Statistics in Clinical Oncology

Handbook of Statistics in Clinical Oncology


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About the Book

A compendium of cutting-edge statistical approaches to solving problems in clinical oncology, Handbook of Statistics in Clinical Oncology, Second Edition focuses on clinical trials in phases I, II, and III, proteomic and genomic studies, complementary outcomes and exploratory methods. Cancer Forum called the first edition a "...good reference book for statisticians who will be designing and analyzing cancer trials." The second edition includes over 1000 references, more than forty world-renowned contributors, and 300 equations, tables, and drawings. During the five years since publication of the first edition, there has been an explosion in the technological capabilities supporting genomic and proteomic research, which are is now firmly implanted in clinical oncology. Reflecting these developments, the second edition contains a new section devoted to analyses of high-throughput data and bioinformatics. Previous chapters of the first edition have been revised to reflect current state of the art in their respective domains. The intended audience is primarily statisticians working in cancer and more generally, in any discipline of medicine. But oncologists too will find the material accessible and will benefit from a rudimentary understanding of the fundamental concepts laid forth in each chapter. Completely revised while keeping the features that made the first edition a bestseller, this is the best single source for up-to-date statistical approaches to research in clinical medicine. More than just an update of the handbook that became the gold standard, this second edition brings you fully into the genomic era of medicine.

Table of Contents:
Phase I Trials. Overviews. Continual Reassessment Method. Pharmacokinetics/Dynamics. Phase II Trials. Overview. Multiple Endpoints. Time-to-Event Endpoints. Selection Designs. Bayesian Analyses. Phase III Trials. Sample Size. Randomization Strategies. Factoral Designs. Equivalence Trials. Early Stopping. Quality of Life. Economic Analyses. Secondary Randomizations. Exploratory Analyses and Prognostic Factors. Overviews. Explained Variation. Regression Trees and Peeling. Serial Biomarkers. Bioinformatics. Overview. Normalization. Genomics. Proteomics. SNPs and Haplotypes. Interpreting Clinical Trials. Pitfalls. Dose-Intensity. Cumulative Incidence. Drop-Outs.

Review :
"…The new topics and contributions in this edition include the recently developed tools for high-dimensional data and bioinformatics in clinical oncology research. A new section has been added emphasizing the importance and rapid developments of these topics over the 5 years since the publication of the first edition. Some of the original sections have been updated to include the state-of-the-art knowledge and tools in all topics. The end result is a comprehensive edited volume covering statistical and bioinformatics methods that provide the foundation for important research and clinical trials in cancer. … Like the last edition, this current edition will be an important addition to the libraries of all health research centers. The book will be prized as a reference book for biostatisticians, biomedical researchers, and oncologists for planning, conducting, analyzing, and interpreting cancer research." —Journal of the American Statistical Association, Vol. 104, No. 487, September 2009 "This is a expanded and revised second edition of a text that was initially well received by the community. The book comprised of 33 chapters, grouped into 6 sections. … The text is extremely well referenced. The authorship represents the leaders in the field. A significant strength of this book is its example-driven approach to the ‘out-of-the-box’ but practical issues faced by those conducting cancer clinical trials. The book provides a critical assessment of the state of science through a thorough review of the methods, applications, and available resources. … a detailed and mostly comprehensive text on the topics of cancer clinical trial design, conduct, analysis, and interpretation." —Daniel Sargent, Sumithra Mandrekar, and Ann Oberg, Mayo Clinic, Biometrics, December 2006


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Product Details
  • ISBN-13: 9781420027761
  • Publisher: Taylor & Francis Ltd
  • Publisher Imprint: Chapman & Hall/CRC
  • Language: English
  • No of Pages: 640
  • ISBN-10: 142002776X
  • Publisher Date: 01 Dec 2005
  • Binding: Digital (delivered electronically)
  • No of Pages: 640


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