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A Reprint of the Investigations Carried Out Under the Supervision of the Therapeutic Research Committee of the Council on Pharmacy and Chemistry of the American Medical Association Volume 1

A Reprint of the Investigations Carried Out Under the Supervision of the Therapeutic Research Committee of the Council on Pharmacy and Chemistry of the American Medical Association Volume 1


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About the Book

This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1913 edition. Excerpt: ...as the average fatal dose for the cat by sub cutaneous injection, it will be seen that Fraenkel s results, so far from being irreconcilable with my own, afford strong corroborative evidence of the persistence of action in the cat. _ If the fatal dose of digitoxin used by Frenkel was really 0.4 mg. per kg. when administered subcutaneously, his animals received only a little more than the single fatal dose within a period of a week, and instead of receiving totals of three, four, seven and eight, times the single fatal dose, respectively, they received totals of three-fifths (this animal survived), one, one and a half, and one and three-fifths times the single fatal ' dose, from which the last three died. One might argue that the specimen of Merck s crystalline digitoxin used by Fraenkel was far more active than the specimens used in this laboratory, and I am well aware that it is commonly stated that the activity of different specimens of all of the digitalis principles varies widely, but while the activity of a given principle _ made by different manufacturers may show great variations, and the product made at different times by the same manufacturer may vary somewhat, the results obtained by numerous observers indicate no very great variation in the activity of Merck s crystalline digitoxin. Among those who have determined the activity of digitoxin and whose results are in fair agreement with those obtained in this laboratory (allowance being made for differences due to different methods of testing), are: Lyons and Famulener,11 Worth Hale12 and K0ppe.13 On the other hand, I know of no one whose results confirm those of-Fraenkel. If the digitoxin used by Fraenkel behaved in the way indicated by him it means...


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Product Details
  • ISBN-13: 9781234268701
  • Publisher: Rarebooksclub.com
  • Publisher Imprint: Rarebooksclub.com
  • Height: 246 mm
  • No of Pages: 54
  • Spine Width: 3 mm
  • Width: 189 mm
  • ISBN-10: 1234268701
  • Publisher Date: 16 Jan 2013
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Weight: 113 gr


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A Reprint of the Investigations Carried Out Under the Supervision of the Therapeutic Research Committee of the Council on Pharmacy and Chemistry of the American Medical Association Volume 1
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A Reprint of the Investigations Carried Out Under the Supervision of the Therapeutic Research Committee of the Council on Pharmacy and Chemistry of the American Medical Association Volume 1
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