Handbook of Proteases in Cancer: Therapeutic Aspects

This handbook provides comprehensive coverage of the application of proteases in cancer therapy. Proteases make up to two percent of the human genome and play a critical role in the tumor microenvironment. The book delves into the applications of natural, synthetic, and non-coding RNAs in cancer therapy. It highlights how effective targeting of relevant proteases can help in cancer diagnosis and treatment. It covers the systems biology and bioinformatics approach in cancer drug development. The book is meant for researchers and professionals in cancer research, biochemistry, and physiology.

Table of Contents:
I. General Aspects 1.1. Influence of Serine Proteases on Bone Morphogenetic Proteins: Insights for Advancing Treatment Paradigms in Breast Cancer Anmol Kapoor, Chandi C. Mandal 1.2. Proteases in Cancer Theranostics Deepmala Karmakar, Sanghamitra Sengupta 1.3. Structural aspects of proteases in cancer therapeutics: A perspective Anirban Nandy, Sima Biswas, Angshuman Bagchi II. Proteases in Cancer Therapy 2.1 Ubiquitin specific proteases: The role and potential in cancer immunotherapy Bee Ling Tan1, Ayman El-Meghawry El-Kenawy2,3, Yin Sim Tor4 2.2. Proteasome, the recycle bin of the cancer cell Amy Dunne Miller1, Vasudha Tandon1, Nilabja Sikdar2, Sourav Banerjee1 2.3. The role of caspase 3 in post chemotherapy breast and colorectal cancer relapse and metastasis. Andreja Leskovac, Sandra Petrovic 2.4. Role of Serine Proteases in Gastric Cancer: Inhibition and Cure Reena Kumari1,2, Kshetrimayum Birla Singh2, Amit Kumar Rai1, Sivakumar Vijayaraghavalu2* 2.5. Serine protease inhibitors in breast cancer therapy Abinaya Elango, Arunkumar Radhakrishnan* 2.6. Serine proteases in cancer: Mechanisms and treatment options Madhu Tanya Singh; Ammu V. V. V. Ravi Kiran; Garikapati Kusuma Kumari; Praveen T. Krishnamurthy* 2.7. Survivin, a moonlighting caspase inhibitor and potential oncotherapeutic target Abdul Basit Baba1, Rajakishore Mishra2, Siddavaram Nagini3 2.8. Ubiquitin-specific proteases for the treatment of breast cancer Suchetana Pal1, Subhasish Sarkar2, Rajlakshmi Laha2, Somasri Dam 2.9. Microbial secretory proteases: a new insight in the field of cancer therapies Nanda Singh, Rima Tapader, Amit Pal 2.10. The emerging role of the γ-secretase inhibitors in cancer management Anuj Kumar Borah1, Chongtham Sovachandra Singh1, Babiangshisha Kharbuli1, Anupam Chatterjee2, Subhendu Chakrabarty3, Amlan Das1 2.11. Cathepsins in cancer therapy and precision medicine Namrata Singh1*, Aqsa Khan2, Asma Mohin Rojewale1, Shinjinee Sengupta2 2.12. The Emerging Role of Calpain 2 Protease as a Therapeutic Target in Breast Cancer Praveen Kumar Chandra Sekar1, Jayakumar Subramaniyan2, Ramakrishnan Veerabathiran1* III. Epigenetic Tools and Stem Cell Therapy 3.1. Calpains, miRNA and cancer: an overview Sajal Chakraborti1*, Mahasweta Ghosh1, Rajabrata Bhuyan2, Dibyapriya Roy Chowdhury1, Tapati Chakraborti1 3.2. The roles of ubiquitin-specific proteases (USPs) in cancer stem cell maintenance. Kuan Ping Anga2, Won Fen Wonga3, Chung Yeng Looi 3.3. Modulatory Effects of Stem Cell Therapy on Cysteine Proteases and Matrix Metaloproteases in Breast Cancer Nour Y. S. Yassin, Noha A. Ahmed, Manal N. Abdel Azeem, Osama M. Ahmed 3.4. Application of metalloproteases in cancer stem cell therapy Uju Dorathy Iliemene1*, Paul T. Olonishuwa1, and Mubarak Labaran Liman2 3.5. Regulatory Mechanisms and Clinical Potential of Epigenetic Targeting in Glioma Yetirajam Rajesh, Suvendu Nandi, Priya Ghosh, Mahitosh Mandal* 3.6. Associations of proteases and long non-coding RNAs in cancer Gaurav Kumar Bhagat1, Dipanjan Guha2, Angshuman Bagchi 3.7. Stem cell-mediated interventions in cancers caused by proteases Farheen Showkata2, Sabra Parveena2, Neetu Badesraa2, Mohmmad Saleem Dar1,2, Md Mehedi Hossaina2, Mir Owais Ayaz1,2, Mohd Jamal Dar1,2 3.8. Stem cell therapy in bone marrow cancer Arjun K R, Girish Kanavi K, Sudipta Choudhury, Mythreyi R, Kanthesh M Basalingappa IV. Nanotechnology Based Therapies 4.1. Protease-targeting nanoparticles for cancer therapy and imaging Sandra Petrovic*, Andreja Leskovac 4.2. Nanomedicine role in proteolytic landscape of breast cancer Sobia Noreen1, Mehwish Ishtiaq1, Sara Hasan1,2, Shazia Akram Ghumman3, Samina Aslam4 4.3. Proteasome Inhibitors and Nano-Delivery Systems for Therapy of Glioblastoma Multiforme Mekala Janaki Ramaiah1, Sahiti Chamarthy1, Janumala Mary Edna1, Katari Sukeerthi2, Nallapaty Srilakshmi2, Prasanna Srinivasan Ramalingam3, Sivakumar Armugam3 4.4. Emerging proteases for molecular imaging and therapy in cancer Presenjit1,2, Shubhra Chaturvedi1, Vishaka Chaudhary1,3, V.P. Singh4, Kaman Singh2, A.K. Mishra1* 4.5. Novel nano technologies associated with Car-T cell therapy in breast cancer Avipsa Hazra1, Ragini Khanna2, Parthiban R3, Gopenath TS4, Kanthesh BM1* V. Bioinformatics and System Biology 5.1. System biology approach of protease Cathepsin K in glioblastoma multiforme Prasanna Srinivasan Ramalingam1, Sivakumar Arumugam1, Purushothaman Balakrishnan2, Janaki Ramaiah Mekala 5.2. Omics technologies for matrix metalloproteinases: MMPs as cancer biomarkers Sherlin Rosita Arockiaraj1, Jay Shree Mathivanan1, Shivani Jambulingam1, Karnati Balaji2, Mahima Bhardwaj2, Pushparaj Annadurai3, Thomas Jebastin1, Abhinav Parashar4, Daniel A. Gideon5* 5.3. Designing Novel Serine Protease Inhibitors against Potential Biomarkers specific to Lung Adenocarcinoma through Systems Biology and Structural Bioinformatics Approaches Anamika Mishra1, Aniket Naha2*, Soundharya H1, Soumitra Nath3*, Nibu Varghese4, Soumya R S5 5.4. System biology and bioinformatics approaches in HTLV-1 protease targeting adult T-cell leukemia disease Chandrabose Selvaraj1, Sanjeev Kumar Singh2, Devadasan Velmurugan 5.5. Protease profiling in lung cancer using bioinformatics tools Protease Profiling in Lung Cancer using Bioinformatics Tools Gowrav Baradwaj, Avipsa Hazra, Dhanu AS and Kanthesh M Basalingappa

About the Author :
Dr. Sajal Chakraborti is associated with the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He conducted postdoctoral research at The Johns Hopkins University School of Medicine, New York Medical College, The University of Utah, and the University of Florida. He has over 35 years of teaching and independent research experience in Biochemistry and Cell Biology. He has published more than 140 original research papers, 25 review articles, and edited 17 books.