Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers-offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various special
Table of Contents:
Overview
Process Chemistry in the Pharmaceutical Industry: An Overview, Kumar G. Gadamasetti
Strategy
Process Research and Development Strategy for Accelerated Projects, Christopher M. Cimarusti
Case Studies
A Practical Synthesis of Ifetroban Sodium, Richard H. Mueller
Synthesis of 5-Lipoxygenase Inhibitors, Ivan Lantos and Richard Matsuoka
Chemistry of Vitamin D: A Challenging Field for Process Research, Masami Okabe
A Highly Optimized and Concise Large Scale Synthesis of a Purine Bronchodilator, Hans-Jurgen Federsel and Edib Jakupovic
Ontazolast: The Evolution of a Process, Vittorio Farina, Karl Grozinger, Hermann Muller-Botticher and Gregory P. Roth
Dilevalol Hydrochloride: Development of a Commercial Process, Derek Walker
Design and Development of Practical Syntheses of LY228729, a Potent 5HT1a Receptor Agonist, Michael J. Martinelli and David L. Varie
Process Research and Development of CGS 19755, an NMDA Antagonist, Peter Giannousis, John Carlson and Marius Leimer
Route Evaluation for the Production of (R)-Levoprotiline, H. U. Blaser, R. Gamboni, B. Pugin, G. Rihs, G. Sedelmeier, E. Schaub, E. Schmidt, B. Schmitz, F. Spindler and Hj. Wetter
The Process Research and Development of DuPont Merck's Cyclic Urea Diols, A New Class of HIV Protease Inhibitors, Pat N. Confalone and Robert E. Waltermire
Practical Enantio- and Diastereo-selective Processes for Azetidinones, T. K. Thiruvengadam, Anantha R. Sudhakar, and Guangzhong Wu
Synthesis of the Common Lactone Moiety of HMG-CoA Reductase Inhibitors, Ian M. McFarlane, Christopher G. Newton and Philippe Pitchen
Enzymatic Intervention and Phase Transfer Catalysis
Chemistry, Biocata
Review :
”...the book successfully achieves its goal of presenting the basic principles and challenges associated with the discovery and scale-up of a commercial manufacturing process of a new drug.”
— Journal of Medicinal Chemistry
”...gives a thorough overview of the challenges facing the modern development chemists in the pharmaceutical industry. It can be recommended to any graduates or postgraduates considering a career in this fascinating field, and even old hands will find much stimulating chemistry in the case studies. “
— Organic Process Research & Development
”...provides a good overview for those wanting an introduction to the science conducted in a process research group. For experienced process chemists, frequent descriptions of creative solutions to difficult problems makes the book worth reading.”
— Journal of the American Chemical Society
”...recommended without reservation. It is suitable not only for the process chemist but also for those involved in preparative work in research in teaching, and for advanced students. It should find a place in every chemical library.”
— Angewandte Chemie
”...presents pharmaceutical synthesis at its best in a very concise and educational way. The wealth of references and illustrations, and the carefully compiled subject index guarantees fast access to further information....the lively style in which chapters are written keeps the reader interested along the way.”
— European Journal of Pharmaceutics and Biopharmaceutics, 2000
