Fundamental Immunology

This text and reference in immunology is now in its Third Edition - revised, updated, and expanded to reflect the growth of information on the immune response, its regulation, and its role in disease pathogenesis. Seven new chapters in the Third Edition focus on advances in characterizing the molecular events that regulate the immune response, understanding the phenomena of antigen processing and presentation, and investigating immune responses to infectious agents. Virtually all the previous edition's chapters have been completely rewritten, many by new contributors, and all chapters include updated references. The expanded section on regulation of the immune response features three new chapters on immunoglobulin class switching; somatic mutation and affinity maturation; and immunosuppression. Antigen processing and presentation, which were only touched on in the previous edition, are now described in a separate chapter in the section on the major histocompatibility complex. Coverage of the role of specific cytokines in the immune response has also been expanded. The revised and expanded section on immunologic mechanisms in disease includes three new chapters on immune responses to infectious agents - viruses, intracellular bacteria, and extracellular bacteria. Chapters on HIV infection, primary immunodeficiency diseases, allergy and hypersensitivity, and immunoparasitology have been rewritten for the Third Edition by new contributors who are authorities on these diseases.

Table of Contents:
Part 1 Introduction: the immune system - an introduction, William E. Paul; the history of immunology, Arthur M. Silverstein. Part 2 The organization and development of the immune system: b lymphocytes, Paul W. Kincade and Jeffrey M. Gimble; t lymphocytes and the thymus, Jonathan Sprent; macrophages, antigen-presenting cells and the phenomena of antigen handling and presentation, Emil R. Unanue; lymphoid tissues and organs, Louis Picker and Mark H. Siegelman; evolution of the immune system, Louis Du Pasquier. Part 3 Antigens, antibodies and receptors: immunogenicity and antigen structures, Jay A. Berzofsky and Ira J. Berkower; immunoglobulins - structure and function, Leon Carayannopoulos and J. Donald Capra; immunoglobulins - molecular genetics, Edward E. Max; t lymphocyte antigen receptors, Stephen M. Hendrick; antigen-antibody interactions and monoclonal antibodies, Jay A. Berzofsky et al. Part 4 Lymphocyte activation, proliferation and differentiation: t lymphocyte activation, Arthur Weiss; b lymphocyte activation, Anthony L. DeFranco; accessory molecules, Ethan M. Shevach. Part 5 The major histocompatibility complex: the major histocompatibility complex, Ted H. Hansen et al; antigen processing and presentation, Ronald N. Germain. Part 6 Regulation of the immune response: immunologic tolerance, Ronald H. Schwartz; t-cell mediated regulation - help and suppression, Frank W. Fitch et al; t-cell-derived cytokines and their receptors, Maureen Howard et al; macrophage-derived mediators, Scott K. Durum and Joost J. Oppenheim; immunoglobulin class switching, Fred D. Finkelman and Clifford M. Snapper; som atic mutation and affinity maturation, Patricia J. Gearhart; idiotypic networks, John F. Kearney; immunosuppression, Nolan H. Sigal and Francis J. Dumont. Part 7 Effector mechanism of immunity: the complement system, M. Kathryn Liszewski and John P. Atkinson; phagocytosis, Steven Greenberg and Samuel C. Silverstein; the functions and mechanisms of action of cytolytic lymphocytes, Gideon Berke; inflammation, John I. Gallin. Part 8 Immunologic mechanisms in disease: autoimmunity and autoimmune disorder, Robert S. Schwartz; transplantation and graft rejection, Hugh Auchincloss, Jr and David H. Sachs; tumor immunology, Hans Schreiber; immunoparasitology, Phillip Scott and F. Alan Sher; immunity to viruses, Rolf M. Zinkernagel; immunity to intracellular bacteria, Stefan H.E. Kaufmann; immunity to extracellular bacteria, Emil C. Gotschlich; vaccines, Gordon L. Ada; primary immunodeficiency diseases, Rebecca H. Buckley; immunology of HIV infection, Anthony S. Fauci and Zeda F. Rosenberg ; allergy and mechanisms of hypersensitivity, Marshall S. Plaut and Eugene M. Zimmerman.